https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Investigation of pathogenesis of chronic obstructive pulmonary disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23630 Wed 11 Apr 2018 17:16:57 AEST ]]> The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30071 Thu 24 Mar 2022 11:36:47 AEDT ]]> Contribution of cell death to the pathogenesis of chronic obstructive pulmonary disease (COPD) https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36167 Mon 26 Oct 2020 11:55:19 AEDT ]]> Multiple respiratory microbiota profiles are associated with lower airway inflammation in children with protracted bacterial bronchitis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35554 Prevotella species. Alpha diversity was unrelated to bacterial biomass, culture of recognized respiratory pathogens, or inflammatory markers. Conclusions: Neutrophilic inflammation in children with PBB was associated with multiple BAL microbiota profiles. Significant associations between inflammatory markers and bacterial biomass, but not alpha diversity, suggest that inflammation in children with PBB is not driven by single pathogenic species. Understanding the role of the entire respiratory microbiota in PBB pathogenesis may be important to determining whether bacteria other than the recognized pathogens contribute to disease recurrence and progression to bronchiectasis.]]> Fri 31 Jan 2020 16:15:09 AEDT ]]>